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World first: Celiac disease VACCINE trialed in Australia – April 09. Will it cure all celiacs & will you still need or want to eat Gluten Free Food?

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Celiac Disease
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World first: Celiac disease vaccine tested in Australia – 9th April Is. It heal all celiac & you will still need or want to eat gluten-free foods?

World first: Celiac disease is testing a vaccine in Australia? 9th April. Will it heal all celiac and you will still need or want to eat gluten-free foods?

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Home Page > Health > Diseases and Conditions > World first: Celiac disease is testing a vaccine in Australia? 9th April. Will it heal all celiac and you will still need or want to eat gluten-free foods?

World first: Celiac disease is testing a vaccine in Australia? 9th April. Will it heal all celiac and you will still need or want to eat gluten-free foods?

Posted: 5 April 2009 | Comments: 0
| Views: 943 |

If you are a celiac, your magic going on -!. In Melbourne, Australia tested from April 2009, it could potentially desensitize people with celiac disease to the point that the villi in their small intestine is not damaged by gluten protein, but with the need for extensive testing in this three-phases of the trial, the vaccine is not ready for publication for several years.

Before we go to is in the details of such a cure should be noted that this vaccine may not be a â? Wonder drug "that permanently immune to the human protein to the gluten, it could" only "desensitize them.Â also be aware that if you choose to undertake the A? Therapy" there is no guarantee how you will react, and the only way to check regularly to see if you have one? cured "regular bowel biopsies would be. As it is known that some people take more than two years to complete, to heal their intestines of gluten damage, is how risky this strategy be? It is expected that the examination be extensive, so that these questions all under one sit? devil's advocate "category, and all can be good.

A more philosophical question is what effect for the cause of your illness on the body. Books have been written that suggest that it processed the increased power of gluten in wheat and other gluten grains as well as increased use in food, which has led an overdose of gluten. Our body then a â? Tipping Point, "where our genetic predisposition to CD is transformed into an active disease. If that's true, would, as it is wise to continue to contain abnormally high amounts of gluten ingestion, again? Healed," just because we can? Sure, life would not make it easier for a gluten-free diet, but perhaps we should wait for gluten to be reduced at the source, the growing areas, before returning filled on a gluten-free diet.

Different types of celiac disease identified

With all these issues under consideration, I'm sure everyone would still be interested in celiac disease a â? Heal. "A July 2007 article about research in Victoria, Australia were conducted showed that" celiac disease – is strongly associated with the human leukocyte antigen (HLA) DQ2 and connected to a lesser extent with HLA DQ8 are. "

"Possess HLA genes are part of the major histocompatibility complex (MHC), which plays a central role in the immune system. HLA-DQ2-mediated celiac disease is common in people of European descent, with positive about 90 percent of these patients for DQ2. Another five percent HLA DQ8. In China and East Asia are rarely DQ2 genes spread throughout DQ8 genes as widely as in Europe. "

So it seems that this preliminary research was to isolate two major versions of celiac disease. However, the molecular mechanisms of the immune response in the two antigens appear to be very different. The researchers discovered that T-cell response in people with celiac disease-associated DQ8 quite differently to the small proteins in gluten than the T-cells in people with the DQ2 form of the disease.

"Right now, a gluten-free diet is the only treatment for celiac disease, but nearly half the people on the diet nor damage is at her small intestine. Consequently, other treatment options, including a vaccine, and three different drugs are in various stages of development. The research team believes Celiac disease could be adapted to the first example of an immune disease where treatments to the genetic makeup of the patient. "

Celiac disease vaccine discovery

The discovery that should lead the creation of the vaccine, that a critical part of the wheat gluten protein that is toxic was the most common genetic variant (HLA DQ2) of celiac disease. "As much as the identity of the toxic component of the adhesive was important, it was the manner stated in the, was that as much more important. By eating gluten in wheat, rye, barley, or for three days ( even a single meal is enough for some people), can immune cells (T cells), which damages the small intestine can be mobilized into the blood for a few short days. The T-cells in the blood are monitored and analyzed to define what a part of gluten to recognize them. The parts of gluten by the vast majority of T cells involved in celiac disease recognized a few "short" fragments of gluten that can remain after their digestion in the intestine are condensed. These gluten fragments can using fairly standard chemistry and are the basis for the Celiac Disease Vaccine. "

The Celiac Disease Vaccine Trials

The initial research began in Oxford, England in 1997. The work was in Australia in 2002 and April 2009 by Bob Anderson of the Walter and Eliza Hall Institute of Medical Research (Melbourne, Australia) is the world's first trials of a vaccine, of celiac disease could reduce or eliminate the need to begin or for gluten-free. In fact, Bob Anderson called the vaccine a "Next-Generation desensitization" that successfully in mice and will soon be tested for celiac disease.

"The vaccine will be tested on 40 volunteers with celiac disease over 11 months to determine that it does not hurt either. In a subsequent PhaseA-2-study designed to determine whether the treatment is effective to get volunteers to treatment and are then challenged with gluten-containing foods. The immune response and bowel is then checked whether tolerance has developed to gluten. The therapy involves repeated injections of solutions of gluten in increasing concentrations. The goal is to desensitize the subjects slowly to hay fever in a similar way and House dust allergy desensitization. "

Test Process

"For a new drug for use in humans in Australia, Europe or North America are not accepted must be successful in Phase 1 (safety) studies, usually up to about 30 volunteers who have progressed to Phase 2 (efficacy) studies to to show that "it works" in people with the disease of interest (typically about 200 volunteers in various locations around the world), and phase 3 (phase two similar, but with several thousand volunteers in many places around the world) ".

Celiac disease vaccine future

To develop because of difficulties in financing, Bob Anderson (Walter and Eliza Hall Institute) co-founded a commercial company called Nexpep to the vaccine. Nucleus Network, Center for Clinical Studies (CCS) at the Alfred Hospital in Melbourne, is conducting Phase 1 trial.

The difficulty he faced in addition to technical issues, is the low level diagnosis of celiac disease and the mass of the associated symptoms has a vaccine to cure unattractive to traditional pharmaceutical companies. These companies always prefer well-defined markets, accurate forecasts payback periods for their R & D and marketing expenses.

Must have the facts to prove that this vaccine, financially viable, the U.S. will be to approve the drug and doctors and celiac patients must accept the treatment. One report estimates that only 600,000 people diagnosed with celiac disease (from the 5 million with celiac disease in North America and Europe). Â Â

Compounded to finance challenges is that previously, there are only three world "randomized controlled" studies on the gluten-free diet – one for children and two adults -. The largest with 57 participants, "

The assessment of the vaccine treatment requires repeated endoscopy and collection of small bowel biopsies that has expensive and un-enjoyable for volunteers. But a recent study in Italy showed that biopsies are still the only â? Almost "guaranteed method to assess the gluten damage. The results of the study showed that" two years after adopting a gluten-free diet, about half of people diagnosed with celiac villous atrophy as bad as first diagnosed when they were continued. Collected only about one-fifth of those with severe intestinal damage (villous atrophy) on a gluten-free diet had (abnormal) blood levels of transglutaminase antibodies, which means that standard blood tests to monitor the activity of the disease were relatively ineffective. "

So while the development of this vaccine is an important step in potentially eliminating celiac disease, philosophical issues remain as topics for the long-term effectiveness of vaccines. As an Australian first of these research applauded by the gluten-free community. We wish the researchers and medical personnel all the best in demystifying this treacherous disease.

Article references are to the gluten-free pages available website.Â

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Bruce Scott Dwyer –
About the author:

In recent years, I have a strong interest in e-marketing and website optimization. My strongest desire is to work in the sustainability of the industry, the large reduction in greenhouse gases. Save the planet, save the people … www.glutenfreepages.com.au

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To cure celiac disease , celiac disease vaccine , gluten free , wheat sensitivity , wheat-free , diet , celiac disease , gluten intolerance , rye intolerance , gluten-market

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